Vitamin C Injection
Vitamin C Injection

[Indications] 1, For the treatment of scurvy, also can be used for a variety of acute and chronic infectious diseases and other auxiliary treatment of purpura. 2. Treatment of chronic iron poisoning: vitamin C promotes the chelation of iron to iron and accelerates the iron excretion. 3, The treatment of idiopathic methemoglobin. 4, The demand for vitamin C increased: (1) patients with chronic hemodialysis, gastrointestinal diseases (chronic diarrhea, stomach or ileal resection), tuberculosis, cancer, ulcer disease, hyperthyroidism, fever, infection, trauma, burns, surgery and so on; (2) for control or select the diet strictly, receiving parenteral nutrition patients, due to malnutrition, weight plummeted, and during pregnancy and lactation; (3) the application of barbiturates, tetracycline, salicylic acid, or vitamin C as urinary acidification medicine.

[Name of drug]

Vitamin C Injection

Chinese Name: 维生素C注射液

Chinese Pinyin: Weishengsu C Zhusheye

 

[Ingredients] Vitamin C

Chemical name: L- ascorbic acid

Chemical formula:

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Molecular formula: C6H8O6

Molecular weight: 176.13

All auxiliary components: Sodium bicarbonate, sodium bicarbonate, EDTA-2Na.

[Character] This product is colorless to slightly yellow transparent liquid.

[Indications]

1, For the treatment of scurvy, also can be used for a variety of acute and chronic infectious diseases and other auxiliary treatment of purpura.
2, Treatment of chronic iron poisoning: vitamin C promotes the chelation of iron to iron and accelerates the iron excretion.
3, The treatment of idiopathic methemoglobin.
4, The following requirements for vitamin C increased:
    (1) Patients with chronic hemodialysis, gastrointestinal diseases (chronic diarrhea, stomach or ileal resection), tuberculosis, cancer, ulcer disease, hyperthyroidism, fever, infection, trauma, burns, surgery etc.;
    (2) Because of strict control or diet, patients who received parenteral nutrition were suffering from malnutrition, weight loss, and during pregnancy and lactation;
    (3) The use of barbiturates, tetracyclines, salicylic acids, or vitamin C as a urinary acidification drug..

[Specification] 5ml:0.5g

 

[Usage and Dosage] Intramuscular or intravenous injection, adult 0.1-0.25g each time, 1-3 times a day; children daily 0.1-0.3g, sub injection, treatment of Keshan disease can be large doses, determined by the physician.

[Adverse Effects]

1, long-term use of daily 2 ~ 3G can cause scurvy after treatment. 2, long-term use of large amounts of vitamin C can sometimes cause urate, cysteine salts or oxalate stones. 3 , rapid intravenous injection can cause dizziness and syncope.

[Contraindicated] The experiment was not conducted and there was no reliable reference.

[Matters Needing Attention]

1,The effect of vitamin C on any of the following circumstances has not been confirmed: the prevention or treatment of cancer, gingivitis, suppuration, bleeding, hematuria, retinal hemorrhage, depression, dental caries, anemia, acne, infertility, aging, arteriosclerosis, ulcer disease, tuberculosis, dysentery, collagen disease, fracture, skin ulcers, fever, drug poisoning embolization of cold.

2, Interference with the diagnosis. A large number of applications will affect the results of the following diagnostic tests:
   (1) Fecal occult blood can cause false positive;
   (2) Automatic analysis of serum lactate dehydrogenase and serum transaminase concentration;
   (3) (copper sulfate method), glucose (glucose oxidase method) can lead to false positive;
   (4) The concentration of oxalate, urate and cysteine in urine increased;
   (5) Serum bilirubin concentration decreased;
   (6) Urinary pH decreased.

 

3, The following should be used with caution:
  (1) Cysteine urine disease;
  (2) Gout;
  (3) High oxalate urine sickness;
  (4) Oxalate deposits;
  (5) Urate nephrolithiasis;
  (6) Diabetes mellitus (because vitamin C may interfere with blood glucose quantification);
  (7) Glucose -6- phosphate dehydrogenase deficiency;
  (8) Hemachromatosis;
  (9) Iron granule anemia or thalassemia;
 (10) Sickle cell anemia.

4, A large number of long-term use of all of a sudden stop, there may be symptoms of scurvy, it should gradually reducing withdrawal.

[Medication for pregnant women and lactating women]  This product can be passed through the placenta and can be secreted into the milk. A high dose of pregnant women can cause a baby's blood disorder.

[Child Medication] The experiment was not conducted and there was no reliable reference.

[Senile Medication] The experiment was not conducted and there was no reliable reference.

 

[Drug Interactions]

1, Large doses of vitamin C can interfere with anticoagulant effect of anticoagulant.
2, With barbiturates or flutter and other combined use, can promote the excretion of vitamin C increased.
3, Sodium cellulose can promote the metabolism of vitamin C oxalate.
4, Long-term or massive use of vitamin C can interfere with the effect of alendronate on ethanol.
5, Salicylic acid can increase the excretion of vitamin C.
6, Not with the basic drugs (such as aminophylline, sodium bicarbonate, sodium glutamate, riboflavin, etc.) three chloro tert butyl alcohol, iron and copper ion (trace) solution compatibility, so as not to affect the curative effect.
7, And vitamin K3 compatibility, because the latter has oxidation, can produce redox reaction, so that the efficacy of the two weakened or disappeared.

 

[Overdose]

1-4g daily, can cause diarrhea, rash, stomach acid, increased gastric reflux, there are visible urinary calculi, urinary oxalate and urate increased discharge, deep vein thrombosis, intravascular hemolysis or clotting, can sometimes cause white blood cell phagocytosis decreased. Daily dosage of more than 5g, can lead to hemolysis, severe can be fatal. Application of a large number of pregnant women, infants can produce scurvy.

 

[Pharmacology and Toxicology]

This product is a vitamin drug. The synthesis of vitamin C in amino acid metabolism, neurotransmitter synthesis, collagen and tissue interstitial cells, can reduce capillary permeability, accelerate blood clotting, stimulate blood clotting function, promote iron absorption in the intestine to blood lipid decreased to increase resistance to infection, and is involved in detoxification function, anti histamine and stop (carcinogen nitrosamine formation).

[Pharmacokinetics]

Protein binding rate is low. Small amounts are stored in plasma and cells, with the highest concentration in gland tissue. Intrahepatic metabolism. A small number of substances excreted by the prototype or metabolite, when the plasma concentration is greater than 14 g/ml, urinary output increased. Can be cleared by hemodialysis.

[Storage] Shading and airtight preservation. The color of the preparation should not be applied after yellowing.

[Packing] Ampoule packing, 5 pcs /  boxes

[Validity]  18 months

[Implementation Criteria] Chinese Pharmacopoeia, 2010 edition, two parts

[Approval Number] SFDA approval number H33021541

[Production Enterprise]

Name of enterprise: Zhejiang Chengyi Pharmaceutical Co., Ltd

Production address: No. 118, Chemical Road, Dongtou District, Wenzhou city,Zhejiang province,China

Phone number: 86-577-6348-3979

Fax number: 86-577-6348-5135

URL:http://en.chengyipharma.com

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