Shen Jun, Deputy Director of the Ministry of Natural Resources of the People's Republic of China, and a delegation came to Chengyi Pharmaceutical for research

On the morning of September 4th, Shen Jun, Deputy Director of the Ministry of Natural Resources and member of the National Marine Strategic Planning and Economic Working Group, accompanied by provincial and municipal experts and leaders, came to Chengyi Pharmaceutical to investigate the development of marine biomedicine.

After listening to the report by Zhao Chunjian, Vice Chairman and Vice General Manager of the company, Director Shen and his delegation expressed appreciation for Chengyi Pharmaceutical's decades of innovation and entrepreneurship rooted in the island, leading the development of Zhejiang's marine biopharmaceutical industry, and becoming the first listed marine biopharmaceutical enterprise in Zhejiang Province, Congratulations on the company's development of a medication for the treatment of elderly bones and joints, "Glucosamine Hydrochloride" (referred to as "Glucosamine"), which has the highest market share in the country. We express our strong interest in the company's continuous research on the pharmacological components and effects of Sargassum fusiforme for many years, and also provide constructive opinions on the issues faced by the company in developing new marine biopharmaceutical products.

Zhao Chunjian introduced that glucosamine hydrochloride is the flagship product of Chengyi Pharmaceutical and the "champion" in the sales of similar drugs in China. Currently, this variety accounts for about 50% of the company's total revenue, with promising prospects; Dongtou is the "hometown of Sargassum fusiforme in China". Developing the medicinal value of Sargassum fusiforme is of great significance for improving the added value of Sargassum fusiforme products, increasing the income of fishermen and farmers, and promoting the development of the marine economy in Dongtou. So eight years ago, Chengyi Pharmaceutical entrusted the Shanghai Institute of Medicine of the Chinese Academy of Sciences to carry out a preliminary study on the effective substances of Sargassum fusiforme and the efficacy of preventing and treating "hypertension, hyperlipidemia, and hyperglycemia", Through the experiments on SHR model rats with spontaneous hypertension, hyperlipidemia induced lipid metabolism disorder model rats and GK rats with spontaneous type 2 diabetes, the preliminary results show that Sargassum fusiforme extract has certain effects on lowering blood pressure, blood lipid and blood sugar. In addition, the medicinal components and pharmacological activities of Sargassum fusiforme in the treatment of elderly dementia jointly carried out by Sincere Pharmaceutical have made gratifying progress, and this project has been included in the national marine economy innovation and development demonstration project.

Zhou Zunlong, Deputy Director of the Planning and Finance Department of the Zhejiang Provincial Oceanic and Fisheries Bureau, stated that the province will provide certain policy support for the development of marine biopharmaceuticals by Chengyi Pharmaceutical, in order to better play its exemplary and leading role. At the same time, he earnestly requests the support of experts and leaders from the Ministry of Natural Resources of the People's Republic of China.

Expert leaders including Zhang Yinghua, Director of the Statistics Management Department of the National Bureau of Statistics, Su Yujuan, Director of the Natural Resources Department, Zhou Dongchun, Director of the Design and Management Department of the Provincial Bureau of Statistics, Zheng Liming, Deputy Director of the Wenzhou Municipal Bureau of Statistics, and Zhang Fangren, Deputy District Mayor of Dongtou District Government, accompanied the survey.

5 Questions about Sincere Pharmaceutical's "Weiergu" Brand Amino Sugar Products

Question 1: What is ammonia sugar?

Amino sugar, also known as deacetylated chitin, or D-glucosamine, is a monosaccharide component that can be extracted from crab and shrimp shells. It is an important component of highly hydrophilic proteoglycans, the fundamental material for synthesizing proteoglycans and collagen fibers in articular cartilage, one of the important nutrients for forming chondrocytes, and a fundamental component of cartilage matrix and joint fluid, which is easily absorbed by the human body.

Question 2: Why does the World Health Organization promote aminosugars so highly?

Arthritis generally refers to inflammatory diseases occurring in human joints and surrounding tissues, which can be divided into dozens of types. It is called "immortal cancer" by the World Health Organization. About 130 million people in China are suffering from osteoarthritis. Its incidence rate is far higher than that of cardiovascular and cerebrovascular diseases, with a high disability rate, which seriously damages the ability of patients to take care of themselves and work.

The raw material of ammonia sugar is extracted from crab shells and shrimp shells in the ocean. Research has found that aminosugars are an important component of highly hydrophilic proteoglycans, which can synthesize collagen in the human body and are easily absorbed by the body. After the unique function of ammonia sugar in repairing articular cartilage was proven, it has attracted the attention of the global medical community. The International Rheumatology Association and the World Health Organization have proposed ammonia sugar as a first-line drug for treating bone and joint diseases.

Question 3: What is the difference between Chengyi Pharmaceutical aminose (Vergu) and other aminose products?

① Self produced materials with high purity. Chengyi Pharmaceutical has both the raw material and preparation production number of glucosamine hydrochloride. The raw materials used in the preparation products are self-produced, with a guaranteed source of raw materials and more reliable quality.

② No excipients, no additives. At present, other ammonia sugar products in the market are supplemented to varying degrees with magnesium stearate, microcrystalline cellulose, PVP, sodium hydroxymethyl starch, starch, sucrose, polyketamine K30, etc. (Vergu) Glucosamine hydrochloride capsules do not contain any excipients or additives. It is more suitable for the elderly and diabetes patients.

③ The specifications are complete and you can choose from them. There are three specifications for (Vergu) Hydrochloric Glucosamine Capsules: 240mg/capsule, 480mg/capsule, and 750mg/capsule. Among them, the specification of 480mg/capsule is still exclusively available in China, with various packaging forms and quantities in board and bottle packaging. There are two capsules three times a day, one capsule three times a day, and one capsule two times a day to meet the needs of different patients.

④ Small size, easier to take orally. Due to the absence of excipients and additives in the same dosage, the product capsule is suitable for oral use, especially for the elderly.

Question 4: What are the relative advantages of Chengyi Pharmaceutical aminoglucose (Vergu) compared to sulfated glucosamine?

Whether it is glucosamine hydrochloride or glucosamine sulfate, its truly physiologically active part is glucosamine. The difference between them lies in the fact that the acid radicals are different, and the two substances are unstable after being absorbed by the stomach. Glucosamine sulfate changes color when it encounters water, so it needs to be co crystallized with sodium chloride or some potassium chloride to be slightly stable. Therefore, the amount of glucosamine sulfate is relatively small, only over 60%, while glucosamine hydrochloride (Vergu) has over 80%. In terms of their stability and purity, glucosamine hydrochloride (Vergu) is superior to glucosamine sulfate.

Question 5: What are the main suitable groups for Chengyi Pharmaceutical aminose (Vergu)?

① Patients with osteoarthritis, used to treat and improve arthritis;

② Manual labor (used to repair worn articular cartilage);

③ Athletes and sports enthusiasts, used to prevent osteoarthritis and sports injuries;

④ IT professionals, drivers, and other sedentary individuals, used to prevent cervical and lumbar spine diseases;

⑤ A beautiful lady who likes to wear high heels, used to prevent foot osteoarthritis;

⑥ For individuals over 35 years old, used to prevent various degenerative arthritis.